Ongoing peer reviewed COS

Projects with external funding or externally peer-reviewed

Health problemFull titleDescriptionCOMET registration numberFunding Body
AbortionSTandardizing Abortion Research outcomes (STAR)Complications of unsafe abortion are one of the main causes of maternal mortality globally. The aim of this project is to develop a core outcome set for the studies with the most common procedures performed on women worldwide to improve the applicability of their findings.
The protocol is available here
779World Health Organization
Cervical cancerCore outcomes for clinical trials of fertility sparing surgery for cervical cancer: a Core Outcome sets for Gynaecological conditions (COGS) project
COGS
Our aim is to develop a core outcome set that can be used in future studies investigating fertility sparing surgical techniques for cervical cancer.791The British Medical Association's Strutt and Harper Grant
EndometriosisDeveloping a Core Outcome Set in Endometriosis
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The International Collaboration to Harmonise Outcomes in Endometriosis (iHOME) aims to produce, disseminate, and implement a core outcome set for endometriosis.

The protocol is available here
691Catalyst Fund - Royal Society of New Zealand &
Endometriosis Millennium Fund, Royal College of Obstetricians and Gynaecologists
Endometrial cancerDevelopment of core outcomes sets to standardise reporting in endometrial cancer
The aim of this project is to develop core outcome sets (COS) for studies concerning the management of atypical endometrial hyperplasia.986Cancer Research UK Population Research Scheme
Endometrial cancerDevelopment of core outcomes sets to standardise reporting in atypical endometrial hyperplasia
The aim of this project is to develop core outcome sets (COS) for studies concerning the management of atypical endometrial hyperplasia.985Cancer Research UK Population Research Scheme
Endometrial cancerDevelopment of a core outcomes set to standardise reporting for fertility sparing treatment of endometrial cancer and endometrial hyperplasiaThe aim of this project is to develop core outcome sets (COS) for studies on fertility sparing treatment of endometrial cancer and endometrial hyperplasia984Cancer Research UK Population Research Scheme
GastroschisisDeveloping a core outcome set for infants born with gastroschisisThe key objectives of this project are: to determine which outcomes are currently reported in studies comparing surgical treatments for gastroschisis and assess the quality of reporting; Prioritise outcomes from patient/parent, paediatric surgical and non-surgical clinician perspectives; Achieve consensus between key stakeholders on a core outcome set for assessing how successful the overall treatment of an infant with gastroschisis has bee; and compare and contrast outcomes prioritised by patients/parents, surgeons and non-surgical clinicians. Study protocol is available here746NIHR Doctoral Research Fellowship
Hirschsprung’s DiseaseDevelopment of a Core Outcome Set for use in Infants with Hirschsprung’s DiseaseA core outcome set will be developed for assessing key outcomes, both short and long term in infants who have undergone surgical intervention for Hirschsprung's Disease.
Study protocol available here
787National Institute for Health Research
Heavy menstrual bleedingCore outcomes for clinical trials of heavy menstrual bleeding: a Core Outcome sets for Gynaecological conditions (COGS) project
COGS
Heavy menstrual bleeding (HMB) is one of the most common reasons for referral to secondary care and affects up to 1 in 5 women of reproductive age. It is a common condition that has a large impact on women’s physical, psychological and social wellbeing and an economic impact due to time taken away from employment and cost to the NHS.

There are many different treatments for HMB including hormonal, medical and surgical interventions. Our aim is to develop a COS that covers all aspects of the condition.
789The Academy of Medical Sciences Starter Grant
Hypertensive disorders in pregnancyInternational Collaboration to Harmonise Outcomes for Pre-Eclampsia (iHOPE)
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iHOPE is working to improve pre-eclampsia research to enable doctors and midwives to provide better treatments and care for pregnant women and their babies.

We invite you to sign up to become an iHOPE collaborator:
  • Deciding which outcomes should be measured involves seeking many different opinions and utilising different methods to reach an agreement.

  • Patients, healthcare professionals, and researchers from all backgrounds and locations are invited to contribute.

  • As an iHOPE collaborator we would invite you to read three short, informative e-mails and take part in an online survey.
The protocol is available here
588The National Institute for Health Research Doctoral Fellowship & The EGA Hospital Charity Travelling Fellowship in Memory of Anne Boutwood, Royal College of Obstetricians and Gynaecologists
Intimate partner violenceForming Core Outcome Sets to Unify Studies on Domestic Violence and Abuse (FoCUS DVA)Domestic violence and abuse (DVA) affects one in four women and is a major public health issue. Recent Cochrane reviews highlight that synthesising evidence on addressing DVA in healthcare settings is limited because of enormous variation in the measurement of effectiveness of intervention. To address this problem, we aim to develop a core outcome set for (a) screening interventions on DVA and (b) advocacy interventions on DVA. This will be achieved via systematic review, stakeholder engagement, qualitative interviews with survivors, and a 2-stage Delphi process.823The Barts Health Charity Academic Clinical Fellowship grant
Intrapartum fetal assessment Developing a core outcome set for intrapartum fetal assessmentThe use of the COS as a minimum across the field of intrapartum fetal assessment would allow for the results of trials and other studies to be effectively compared, contrasted and combined, as appropriate.741Health Research Board (Ireland)
Intrauterine growth restriction Developing a core outcome set for clinical trials in intrauterine growth restrictionDeveloping a COS for use in all studies of the screening, prevention and treatment of intrauterine growth restriction is timely and important. This use of the COS as a minimum across an entire research area would allow for the results of trials and other studies to be effectively compared, contrasted and combined, as appropriate.689Health Research Board (Ireland)
Maternity care Salutogenic Intrapartum Core Outcomes (SIPCO): Identification of a minimum dataset using an international eDelphi consensus processUsing a list of salutogenically-focused reported outcomes identified in a systematic review of systematic reviews of intrapartum interventions, conducted by the principal investigators to the project, and others, we propose to develop, through expert opinion and consensus, a set of salutogenic intrapartum core outcomes (SIPCO) for use in maternity care research and daily practice.

The protocol is available here
673Non-funded, but performed as part of work within a COST Action (ISO907)
MiscarriageCore outcome measures for prevention of miscarriage trials The aim of this study will be to develop core outcome measures for trials in the prevention of miscarriage.815The National Institute for Health Research Post doctoral Fellowship
MiscarriageCore outcome measures for medical management of miscarriageThe aim of this study will be to develop core outcome measures for the medical management of miscarriage816The National Institute for Health Research Post doctoral Fellowship
MiscarriageCore outcome measures for surgical management of miscarriageThe aim of this study will be to develop core outcome measures for the surgical management of miscarriage.679The National Institute for Health Research Post doctoral Fellowship
NeonatologyCore Outcomes in Neonatology (COIN)
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The aim of this study is to develop a neonatal Core Outcome Set that are linked to data that are routinely recorded during clinical care. Development and use of a core outcome set will ensure that outcomes of importance to all stakeholders, including patients and parents, are collected and reported in a standard way.842Imperial College Doctoral Fellowship
ObesityNetwork for Preconception and early Pregnancy Randomised Controlled TrialsThis project will:
  • Identify core neonatal outcomes for preconception and early pregnancy randomised controlled trials that aim to break the intergenerational cycle of obesity (and diabetes)

  • Build a network of studies to improve pregnancy in overweight and obese women through preconception and early gestation lifestyle programs.
784The University of Western Australia Research Collaboration Award
Postpartum haemorrhageCore outcome sets for the prevention and treatment of postpartum haemorrhagePostpartum Haemorrhage (PPH) is the leading cause of maternal mortality worldwide, but evidence around prevention and treatment interventions is difficult to interpret due to heterogeneity in endpoints.

This project will develop Core Outcomes Sets (COS) for (1) prevention and (2) treatment of PPH by consulting relevant stakeholders using a Delphi survey and face to face meeting.

To explore best methodology for development of COS, we will do one Delphi on a small group of experts and a second Delphi on a larger stakeholder group and agree the final COS at the face to face consensus meeting.
706The British Medical Association's Strutt and Harper Grant